Phagocytosis of neuron

This image was created by Emma Vought from the Medical University of South Carolina, who works there as a multimedia specialist and has a master’s degree in medical illustrations.

In the image: microglia phagocytosis of the stressed neuron. (Blue – complement C3d, Orange – Microglia).

The image was used as an illustration to the article about the local inhibitor of complement-mediated phagocytosis, developed by researchers from the Medical University of South Carolina. It may be useful in the therapy of ischemic stroke. Around the central zone of necrosis (the “penumbra zone”), neurons cease to perform normal functions and go into the “survival” mode, the immune system recognizes such neurons as those which are preparing for death and, with the help of a complement system, such neurons are being destroyed by phagocytosis.

P.S: more about the subject here:
Novel therapy inhibits complement to preserve neurons and reduce inflammation after stroke

Targeted complement inhibition salvages stressed neurons and inhibits neuroinflammation after stroke in mice.

Oleksandr Petrenko
Oleksandr Petrenko
M.D., PhD student

A medical doctor and researher, studying rare diseases.